Product Overview
Doxifluridine | T1600 | TargetMol Chemicals
CAS: 3094-09-5
Smiles: [C@H]1(n2c(=O)[nH]c(=O)c(c2)F)[C@@H]([C@@H]([C@H](O1)C)O)O
Formula: C9H11FN2O5
Pathway: Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Target: Nucleoside Antimetabolite/Analog|||DNA/RNA Synthesis
Receptor: N/A
Bioactivity: Doxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.
Molecular Weight: 246, 19
