Product Overview
Duocarmycin A | T15180 | TargetMol Chemicals
CAS: 118292-34-5
Smiles: [H][C@]12C[C@@]11C(=CC(=O)C3=C1C(=O)[C@@](C)(N3)C(=O)OC)N(C2)C(=O)c1cc2cc(OC)c(OC)c(OC)c2[nH]1
Formula: C26H25N3O8
Pathway: Apoptosis|||Proteases/Proteasome
Target: Caspase
Receptor: N/A
Bioactivity: Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.
Molecular Weight: 507, 499
