Product Overview
E 2012 | T15184 | TargetMol Chemicals
CAS: 870843-42-8
Smiles: COc1cc(\C=C2/CCCN([C@@H](C)c3ccc(F)cc3)C2=O)ccc1-n1cnc(C)c1
Formula: C25H26FN3O2
Pathway: Neuroscience|||Proteases/Proteasome|||Stem Cells
Target: Gamma-secretase
Receptor: N/A
Bioactivity: E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat.
Molecular Weight: 419, 5
