Product Overview
(E)-SI-2 | T9836 | TargetMol Chemicals
CAS: 380537-35-9
Smiles: CN1C2=CC=CC=C2N=C1N/N=C(C3=NC=CC=C3)\C
Formula: C15H15N5
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: (E)-SI-2 is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2. It selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells.
Molecular Weight: 265, 31
