Product Overview
(E)-SIS3 | T3636 | TargetMol Chemicals
CAS: 521984-48-5
Smiles: Cl.COc1cc2CCN(Cc2cc1OC)C(=O)\C=C\c1c(-c2ccccc2)n(C)c2ncccc12
Formula: C28H28ClN3O3
Pathway: Stem Cells
Target: TGF-beta/Smad
Receptor: N/A
Bioactivity: SIS3, a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.
Molecular Weight: 490
