Product Overview
E6446 | T4206 | TargetMol Chemicals
CAS: 1219925-73-1
Smiles: C(COc1ccc(cc1)-c1nc2ccc(OCCCN3CCCC3)cc2o1)CN1CCCC1
Formula: C27H35N3O3
Pathway: Immunology/Inflammation
Target: TLR
Receptor: N/A
Bioactivity: E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When administered to mice, this compound suppress responses to challenge doses of cytidine-phosphate-guanidine (CpG)-containing DNA, which stimulates TLR9.
Molecular Weight: 449, 595
