Product Overview
E7449 | T4471 | TargetMol Chemicals
CAS: 1140964-99-3
Smiles: O=c1[nH]nc2[nH]c(CN3Cc4ccccc4C3)nc3cccc1c23
Formula: C18H15N5O
Pathway: Chromatin/Epigenetic|||DNA Damage/DNA Repair|||Others
Target: Others|||PARP
Receptor: N/A
Bioactivity: E7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ～50 and ～50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.
Molecular Weight: 317, 352