Product Overview
Ebselen | T0825 | TargetMol Chemicals
CAS: 60940-34-3
Smiles: O=c1n([se]c2ccccc12)-c1ccccc1
Formula: C13H9NOSe
Pathway: Immunology/Inflammation|||Membrane transporter/Ion channel|||Metabolism|||Microbiology/Virology|||Neuroscience|||Proteases/Proteasome
Target: Phosphatase|||Virus Protease|||Calcium Channel|||COX|||HIV Protease
Receptor: N/A
Bioactivity: Ebselen is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity.
Molecular Weight: 274, 192
