Product Overview
Edicotinib | T15199 | TargetMol Chemicals
CAS: 1142363-52-7
Smiles: CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
Formula: C27H35N5O2
Pathway: Angiogenesis|||Tyrosine Kinase/Adaptors
Target: c-Fms|||FLT|||CSF-1R|||c-Kit
Receptor: N/A
Bioactivity: Edicotinib is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the potential for Alzheimer's disease and rheumatoid arthritis treatment.
Molecular Weight: 461, 61