Product Overview
Emedastine | T3979 | TargetMol Chemicals
CAS: 87233-61-2
Smiles: CCOCCn1c(nc2ccccc12)N1CCCN(C)CC1
Formula: C17H26N4O
Pathway: GPCR/G Protein|||Immunology/Inflammation|||Neuroscience
Target: Histamine Receptor
Receptor: N/A
Bioactivity: Emedastine is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors.
Molecular Weight: 302, 422
