Product Overview
Endostatin (84-114)-NH2 (JKC367) | TP2245 | TargetMol Chemicals
CAS: TP2245
Smiles: O=C(NCC(=O)N[C@](C)([H])C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(C/C1=C/C=CC=C1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C/C2=C/C=CC=C2)C(=O)N[C@@]([H])(CC(=O)O)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CC(C)(C)[H])C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@]([H])(CC=3N=CNC=3)C(=O)N4CCC[C@]4([H])C(=O)N[C@]([H])(C(=O)N[C@@]([H])(C/C5=C/NC=6C=CC=CC5=6)C(=O)N7CCC[C@@]7([H])C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CO)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(C/C9=C/NC=8C=CC=CC=89)C(=O)N[C@@]([H])(C/C%10=C/NC=N%10)C(=O)NCC(=O)N[C@]([H])(CO)C(=O)N[C@]([H])(CC(O)=O)C(=O)N%11CCC[C@@]%11([H])C(=O)N[C@@]([H])(CC(N)=O)C(N)=O)C(C)(C)[H])[C@](C)(O)[H])C(C)(C)[H])[C@](C)([H])CC)[C@@]%12([H])NCCC%12
Formula: C161H236N48O43
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: Endostatin is a potent inhibitor of primary tumor growth and endothelial cell proliferation and migration. Recombinant endostatin potently inhibited angiogenesis, maintains metastases at a low level, and suppressed tumors, a reduction of over 150-fold. Endostatin showed no toxicity to mice, no evidence of drug resistance, and no regrowth of tumors.
Molecular Weight: 3531, 9
