Product Overview
Ensartinib hydrochloride | T22324 | TargetMol Chemicals
CAS: 2137030-98-7
Smiles: Cl.Cl.CC(Oc1cc(nnc1N)C(=O)Nc1ccc(cc1)C(=O)N1CC(C)NC(C)C1)c1c(Cl)ccc(F)c1Cl
Formula: C26H29Cl4FN6O3
Pathway: Angiogenesis|||Others|||Tyrosine Kinase/Adaptors
Target: Others|||Trk receptor|||c-Met/HGFR|||ALK
Receptor: N/A
Bioactivity: Ensartinib dihydrochloride is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both wild-type ALK and ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM.
Molecular Weight: 634, 36
