Product Overview
Ensifentrine | T25376 | TargetMol Chemicals
CAS: 1884461-72-6
Smiles: COc1cc2CCn3c(c\c(=N/c4c(C)cc(C)cc4C)n(CCNC(N)=O)c3=O)-c2cc1OC
Formula: C26H31N5O4
Pathway: Metabolism
Target: PDE
Receptor: N/A
Bioactivity: Ensifentrine is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3, 440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical development for the treatment of asthma and COPD and, potentially, cystic fibrosis.
Molecular Weight: 477, 565