Product Overview
Eurycomalactone | TN1637 | TargetMol Chemicals
CAS: 23062-24-0
Smiles: [H][C@]1(C)[C@@]2([H])OC(=O)[C@]1([H])[C@]1(C)C(=O)C[C@@]3([H])C(C)=CC(=O)[C@@H](O)[C@]3(C)[C@@]1([H])[C@H]2O
Formula: C19H24O6
Pathway: Microbiology/Virology|||NF-Κb
Target: Anti-infection|||NF-κB
Receptor: N/A
Bioactivity: Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-induced degradation of IκBα or the phosphorylation of IKKα/β and IκBα.
Molecular Weight: 348, 395