Product Overview
FIIN-4 | T27319 | TargetMol Chemicals
CAS: 2093088-81-2
Smiles: COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc2N(Cc2cccc(NC(=O)C=C)c2)C1=O
Formula: C35H38N8O4
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: FIIN-4 is a first-in-class covalent inhibitor of FGFR (Fibroblast Growth Factor Receptor) that inhibits metastatic breast cancer. FIIN-4 effectively blocks 3D metastatic outgrowth. In vivo application of FIIN-4 potently inhibited the growth of metastatic, patient-derived breast cancer xenografts and murine-derived metastases growing within the pulmonary microenvironment.
Molecular Weight: 634, 741
