Product Overview
Firibastat | T28482 | TargetMol Chemicals
CAS: 648927-86-0
Smiles: N[C@@H](CCS(O)(=O)=O)CSSC[C@@H](N)CCS(O)(=O)=O
Formula: C8H20N2O6S4
Pathway: Metabolism
Target: Aminopeptidase
Receptor: N/A
Bioactivity: QGC-001 is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. QGC-001 selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats[1][2].
Molecular Weight: 368, 5