Product Overview
Flavokawain A | T3S0737 | TargetMol Chemicals
CAS: 3420-72-2
Smiles: COc1ccc(C=CC(c2c(OC)cc(OC)cc2O)=O)cc1
Formula: C18H18O5
Pathway: Apoptosis|||MAPK
Target: Apoptosis|||p38 MAPK
Receptor: N/A
Bioactivity: NSC 37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model, prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC 37445 can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. 3. Flavokawain A may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.
Molecular Weight: 314, 33
