Product Overview
Flindokalner | T15286 | TargetMol Chemicals
CAS: 187523-35-9
Smiles: COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F
Formula: C16H10ClF4NO2
Pathway: Membrane transporter/Ion channel
Target: Potassium Channel
Receptor: N/A
Bioactivity: Flindokalner is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner displays a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM) and acts as a negative modulator of GABAA receptors and it also shows anxiolytic efficacy in vivo.
Molecular Weight: 359, 7