Product Overview
Fludarabine Phosphate | T6501 | TargetMol Chemicals
CAS: 75607-67-9
Smiles: Nc1nc(F)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O
Formula: C10H13FN5O7P
Pathway: Apoptosis|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Target: Apoptosis|||Nucleoside Antimetabolite/Analog|||DNA/RNA Synthesis
Receptor: N/A
Bioactivity: Fludarabine Phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase, and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.
Molecular Weight: 365, 214
