Product Overview
FM-381 | T5091 | TargetMol Chemicals
CAS: 2226521-65-7
Smiles: CN(C)C(=O)C(=C\c1ccc(o1)-c1nc2cnc3[nH]ccc3c2n1C1CCCCC1)\C#N
Formula: C24H24N6O2
Pathway: Angiogenesis|||Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells
Target: JAK
Receptor: N/A
Bioactivity: FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
Molecular Weight: 428, 496
