Product Overview
FzM1.8 | T15363 | TargetMol Chemicals
CAS: 2204290-85-5
Smiles: OC(=O)c1cc(O)cc(NC(=O)Nc2ccc3ccccc3c2)c1
Formula: C18H14N2O4
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: FzM1.8 is an FZD4 allosteric agonist (pEC50: 6.4. FzM1.8). It binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. It also stimulates the release of the Gβγ subunit that in turn activates PI3K.
Molecular Weight: 322, 32