Gambogic Acid | T6185

(No reviews yet) Write a Review
€170.00 - €679.00
SKU:
TMC-T6185
Availability:
IN STOCK
Adding to cart… The item has been added

Product Overview

Gambogic Acid | T6185 | TargetMol Chemicals

CAS: 2752-65-0

Smiles: CC(C)=CCC[C@@]1(C)Oc2c(CC=C(C)C)c3O[C@@]45[C@H]6C[C@@H](C=C4C(=O)c3c(O)c2C=C1)C(=O)[C@]5(C\C=C(\C)C(O)=O)OC6(C)C

Formula: C38H44O8

Pathway: Apoptosis|||Autophagy

Target: BCL|||Autophagy

Receptor: N/A

Bioactivity: Gambogic Acid ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 uM, respectively.

Molecular Weight: 628, 762

Reviews

(No reviews yet) Write a Review