Product Overview
Gandotinib | T2638 | TargetMol Chemicals
CAS: 1229236-86-5
Smiles: Cc1cc(Nc2cc(CN3CCOCC3)c3nc(C)c(Cc4ccc(Cl)cc4F)n3n2)[nH]n1
Formula: C23H25ClFN7O
Pathway: Angiogenesis|||Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells|||Tyrosine Kinase/Adaptors
Target: VEGFR|||FGFR|||FLT|||JAK
Receptor: N/A
Bioactivity: LY2784544(Gandotinib) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3.
Molecular Weight: 469, 95
