Product Overview
Ganoderic acid A | T6S1141 | TargetMol Chemicals
CAS: 81907-62-2
Smiles: CC(CC(=O)CC(C)C(O)=O)C1CC(O)C2(C)C3=C(C(=O)CC12C)C1(C)CCC(=O)C(C)(C)C1CC3O
Formula: C30H44O7
Pathway: Apoptosis|||Autophagy|||Metabolism|||NF-Κb
Target: Apoptosis|||NF-κB|||Endogenous Metabolite|||Autophagy
Receptor: N/A
Bioactivity: 1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis and suppression of invasion in human osteosarcoma HOS and MG-63 cells. 3. Ganoderic acid A promotes cisplatin-induced cell death by enhancing the sensitivity of HepG2 cells to cisplatin mainly via the signal transducer and activator of transcription 3 suppression, significantly suppresses IL-6-induced signal transducer and activator of transcription 3 phosphorylation.
Molecular Weight: 516, 675
