Product Overview
Gemcitabine elaidate | T15378 | TargetMol Chemicals
CAS: 210829-30-4
Smiles: CCCCCCCC\C=C\CCCCCCCC(=O)OC[C@H]1O[C@@H](n2ccc(N)nc2=O)C(F)(F)[C@@H]1O
Formula: C27H43F2N3O5
Pathway: Apoptosis|||Autophagy|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Target: Apoptosis|||Nucleoside Antimetabolite/Analog|||Autophagy
Receptor: N/A
Bioactivity: Gemcitabine elaidate, is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.
Molecular Weight: 527, 654
