Product Overview
Gemfibrozil | T1415 | TargetMol Chemicals
CAS: 25812-30-0
Smiles: Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1
Formula: C15H22O3
Pathway: DNA Damage/DNA Repair|||GPCR/G Protein|||Metabolism|||Neuroscience
Target: P450|||Adrenergic Receptor|||PPAR
Receptor: N/A
Bioactivity: Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).
Molecular Weight: 250, 338
