Product Overview
GI254023X | T7522 | TargetMol Chemicals
CAS: 260264-93-5
Smiles: O=C(N[C@H](C(NC)=O)C(C)(C)C)[C@@H]([C@@H](N(C=O)O)C)CCCC1=CC=CC=C1
Formula: C21H33N3O4
Pathway: Immunology/Inflammation|||Proteases/Proteasome
Target: MMP|||Immunology/Inflammation related
Receptor: N/A
Bioactivity: GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). GI254023X can remarkably inhibit the proliferation and induce the apoptosis of H929 cells. Its mechanism may be associated with inbihition of Notch1 activation.
Molecular Weight: 391, 5
