Product Overview
Gilteritinib | T4409 | TargetMol Chemicals
CAS: 1254053-43-4
Smiles: CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(CC3)N3CCN(C)CC3)c(OC)c2)nc1NC1CCOCC1
Formula: C29H44N8O3
Pathway: Angiogenesis|||Tyrosine Kinase/Adaptors
Target: FLT|||TAM Receptor|||c-Kit
Receptor: N/A
Bioactivity: Gilteritinib is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively). In preClinicalal studies, gilteritinib showed strong antileukemic and antitumor effects. Gilteritinib is currently in several Phase 3 Clinicalal trials for acute myeloid leukemia.
Molecular Weight: 552, 724