Product Overview
Gliotoxin | TN1694 | TargetMol Chemicals
CAS: 67-99-2
Smiles: CN([C@]1(CO)SS[C@@]2(CC([C@H]34)=CC=C[C@@H]4O)N3C1=O)C2=O
Formula: C13H14N2O4S2
Pathway: Apoptosis|||Cytoskeletal Signaling|||Immunology/Inflammation|||Microbiology/Virology|||Neuroscience|||NF-Κb|||Stem Cells|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||NF-κB|||Wnt/beta-catenin|||COX|||PKA|||Antibacterial|||Antifection
Receptor: N/A
Bioactivity: Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis.
Molecular Weight: 326, 4
