Product Overview
GMB-475 | T8488 | TargetMol Chemicals
CAS: 2490599-18-1
Smiles: CC1=C(SC=N1)C1=CC=C(CNC(=O)C2CC(O)CN2C(=O)C(NC(=O)COCCOC2=CC=C(C=C2)C2=CC(NC3=CC=C(OC(F)(F)F)C=C3)=NC=N2)C(C)(C)C)C=C1
Formula: C43H4F3NOS
Pathway: Angiogenesis|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors
Target: Bcr-Abl
Receptor: N/A
Bioactivity: GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein
Molecular Weight: 861, 93
