Product Overview
GNE-490 | T22339 | TargetMol Chemicals
CAS: 1033739-92-2
Smiles: Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2sc(cc2n1)C(C)(C)O
Formula: C18H22N6O2S
Pathway: Others|||PI3K/Akt/mTOR signaling
Target: Others|||PI3K
Receptor: N/A
Bioactivity: GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50 = 750 nM).
Molecular Weight: 386, 47
