Product Overview
GNE-617 hydrochloride (1362154-70-8 free base) | T22801 | TargetMol Chemicals
CAS: T22801
Smiles: FC1=CC(F)=CC(S(C2=CC=C(C/N=C(O)/C3=CN4C=CN=C4C=C3)C=C2)(=O)=O)=C1.Cl
Formula: C21H16ClF2N3O3S
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: GNE-617 hydrochloride is a potent and competitive inhibitor of nicotinamide phosphoribosyltransferase (IC50: 5nM). GNE-617 hydrochloride reduces the NAD levels in a > 95% reduction in both NAPRT1-deficient and NAPRT1-proficient cell lines and exerts (EC50: 0.54nM to 4.69nM).
Molecular Weight: 463, 88
