Product Overview
GNF351 | T15410 | TargetMol Chemicals
CAS: 1227634-69-6
Smiles: CC(C)n1cnc2c(NCCc3c[nH]c4ccccc34)nc(nc12)-c1cncc(C)c1
Formula: C24H25N7
Pathway: Immunology/Inflammation
Target: Aryl Hydrocarbon Receptor
Receptor: N/A
Bioactivity: GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM).
Molecular Weight: 411, 513