Product Overview
Golvatinib | T6517 | TargetMol Chemicals
CAS: 928037-13-2
Smiles: CN1CCN(CC1)C1CCN(CC1)C(=O)Nc1cc(Oc2ccc(NC(=O)C3(CC3)C(=O)Nc3ccc(F)cc3)c(F)c2)ccn1
Formula: C33H37F2N7O4
Pathway: Angiogenesis|||Tyrosine Kinase/Adaptors
Target: VEGFR|||c-Met/HGFR
Receptor: N/A
Bioactivity: Golvatinib is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of tumor cell types and play important roles in tumor cell growth, migration and angiogenesis.
Molecular Weight: 633, 701
