Product Overview
GSK-1070916 | T6129 | TargetMol Chemicals
CAS: 942918-07-2
Smiles: CCn1cc(c(n1)-c1ccc(NC(=O)N(C)C)cc1)-c1ccnc2[nH]c(cc12)-c1cccc(CN(C)C)c1
Formula: C30H33N7O
Pathway: Angiogenesis|||Apoptosis|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||Tie-2|||FLT|||AMPK|||Aurora Kinase
Receptor: N/A
Bioactivity: GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.
Molecular Weight: 507, 642
