Product Overview
GSK-25 | T4488 | TargetMol Chemicals
CAS: 874119-56-9
Smiles: CC1=C(C(N=C(N1)c1ccnc(Cl)c1)c1ccc(Cl)cc1F)C(=O)Nc1cc2cn[nH]c2cc1F
Formula: C24H16Cl2F2N6O
Pathway: Cell Cycle/Checkpoint|||Cytoskeletal Signaling|||MAPK|||PI3K/Akt/mTOR signaling|||Stem Cells
Target: ROCK|||S6 Kinase|||mTOR
Receptor: N/A
Bioactivity: GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
Molecular Weight: 513, 33
