Product Overview
GSK180736A | T3513 | TargetMol Chemicals
CAS: 817194-38-0
Smiles: CC1=C(C(NC(=O)N1)c1ccc(F)cc1)C(=O)Nc1ccc2[nH]ncc2c1
Formula: C19H16FN5O2
Pathway: Cell Cycle/Checkpoint|||Cytoskeletal Signaling|||GPCR/G Protein|||Stem Cells|||Tyrosine Kinase/Adaptors
Target: ROCK|||GRK|||PKA
Receptor: N/A
Bioactivity: GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM).
Molecular Weight: 365, 368
