Product Overview
Guanfu base A | T8182 | TargetMol Chemicals
CAS: 1394-48-5
Smiles: CC(=O)O[C@H]1C[C@]2(C)CN3[C@H]4C[C@]56CC(=C)[C@@H]7[C@@H](O)[C@H]5[C@](C1)([C@@H]24)[C@H]3[C@@]6(O)C7OC(C)=O
Formula: C24H31NO6
Pathway: Angiogenesis|||JAK/STAT signaling|||Membrane transporter/Ion channel|||Metabolism|||Tyrosine Kinase/Adaptors
Target: P450|||Potassium Channel|||HER
Receptor: N/A
Bioactivity: Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
Molecular Weight: 429, 513
