Product Overview
HBF-0259 | T27527 | TargetMol Chemicals
CAS: 957011-15-3
Smiles: Fc1cccc(Cl)c1C1CC(Nc2nnnn12)c1ccc(Cl)cc1
Formula: C16H12Cl2FN5
Pathway: Immunology/Inflammation
Target: Antiviral
Receptor: N/A
Bioactivity: HBF-0259 is an inhibitors of hepatitis B virus surface antigen (HBsAg) secretion with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells. HBF-0259 had a EC50 of approximately 1.5 microM in a secondary, HBV-expressing cell line, with a concentration that exhibited 50% cytotoxicity of >50 microM. The equilibrium concentration of HBF-0259 in aqueous solution at physiological pH was 15 to 16 microM; the selective index was thus >9.
Molecular Weight: 364, 21
