Product Overview
HCV-371 | T32050 | TargetMol Chemicals
CAS: 675184-27-7
Smiles: CCC[C@]1(CC(O)=O)OCCc2c1[nH]c1c(C)ccc(C#N)c21
Formula: C18H20N2O3
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: HCV-371 is a potent selective HCV NS5B polymerase inhibitor that shows broad inhibitory activity against NS5B RDRP and no inhibitory activity against a set of human polymerases (including mitochondrial DNA polymerase γ and other unrelated viral polymerases). This indicates that it is specific for HCV polymerase. Fluorescence binding studies have shown that HCV-371 binds to NS5b at an apparent dissociation constant of 150 nM, resulting in high selectivity and non-cytotoxicity in antiviral tests.
Molecular Weight: 312, 369
