Product Overview
HJB97 | T15484 | TargetMol Chemicals
CAS: 2093391-24-1
Smiles: CCn1nc(cc1Nc1nc(nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12)C(=O)NC)C1CC1
Formula: C26H28N8O3
Pathway: Chromatin/Epigenetic
Target: Epigenetic Reader Domain
Receptor: N/A
Bioactivity: HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively).
Molecular Weight: 500, 563