Product Overview
Homoharringtonine | T3380 | TargetMol Chemicals
CAS: 26833-87-4
Smiles: COC(=O)C[C@](O)(CCCC(C)(C)O)C(=O)O[C@H]1[C@H]2c3cc4OCOc4cc3CCN3CCC[C@]23C=C1OC
Formula: C29H39NO9
Pathway: JAK/STAT signaling|||Stem Cells
Target: STAT
Receptor: N/A
Bioactivity: Homoharringtonine is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients with myelodysplastic syndrome. Homoharringtonine enhances the paracellular permeability of Caco-2 cell monolayers by modulating the protein expression and localization of claudin isoforms. Homoharringtonine has anti-Y and antileukemic activities may have the potential ability to treat acute, chronic myeloid leukemia and Gefitinib-resistant NSCLC.
Molecular Weight: 545, 629
