Product Overview
IACS-010759 hydrochloride | T27568 | TargetMol Chemicals
CAS: 1807523-99-4
Smiles: Cl.Cc1nc(nn1Cc1cccc(c1)N1CCC(CC1)S(C)(=O)=O)-c1nc(no1)-c1ccc(OC(F)(F)F)cc1
Formula: C25H26ClF3N6O4S
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NAD+ in immunoprecipitated complex I in low nM range. IACS-10759 shows significant efficacy in multiple tumor indications both in vitro and in vivo.
Molecular Weight: 599, 03
