Product Overview
IC 86621 | T9760 | TargetMol Chemicals
CAS: 404009-40-1
Smiles: O=C(C1=CC=C(C=C1O)N2CCOCC2)C
Formula: C12H15NO3
Pathway: DNA Damage/DNA Repair|||PI3K/Akt/mTOR signaling
Target: DNA-PK
Receptor: N/A
Bioactivity: IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cellular DSB repair.
Molecular Weight: 221, 25
