Product Overview
IDH-305 | T15550 | TargetMol Chemicals
CAS: 1628805-46-8
Smiles: C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)n1
Formula: C23H22F4N6O2
Pathway: Metabolism
Target: Dehydrogenase
Receptor: N/A
Bioactivity: IDH-305 is an orally available, mutation-selective, and brain-penetrant IDH1 inhibitor targeting the IDH1 (R132) mutation. IDH-305 is 200-fold more selective for mutant IDH1 isoforms than wild type with IC50s of 27 nM, 28 nM and 6.14 nM for IDH1R132H, IDH1R132C and IDH1WT, respectively.
Molecular Weight: 490, 463
