Product Overview
IMM-01 | T25529 | TargetMol Chemicals
CAS: 218795-74-5
Smiles: CC(C)(C)NC(=S)N\N=C\c1ccc(O)cc1O
Formula: C12H17N3O2S
Pathway: GPCR/G Protein
Target: GTPase
Receptor: N/A
Bioactivity: IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division. GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD autoregulatory domains, which releases the FH2 domain to modulate actin and microtubule dynamics[1].
Molecular Weight: 267, 35
