Product Overview
Inavolisib | T15375 | TargetMol Chemicals
CAS: 2060571-02-8
Smiles: C[C@H](Nc1ccc2-c3nc(cn3CCOc2c1)N1[C@@H](COC1=O)C(F)F)C(N)=O
Formula: C18H19F2N5O4
Pathway: Apoptosis|||PI3K/Akt/mTOR signaling
Target: Apoptosis|||PI3K
Receptor: N/A
Bioactivity: GDC-0077 is an orally available and selective inhibitor of PI3Kα (IC50=0.038 nM). GDC-0077 is more selective for mutant versus wild-type PI3Kα. GDC-0077 exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3.
Molecular Weight: 407, 378