Product Overview
INCB054329 | T22345 | TargetMol Chemicals
CAS: 1628607-64-6
Smiles: O=C1N2C3=C(C(=CC=C3N1)C=4C(C)=NOC4C)OC[C@@]2(C5=CC=CC=N5)[H]
Formula: C19H16N4O3
Pathway: Chromatin/Epigenetic
Target: Epigenetic Reader Domain
Receptor: N/A
Bioactivity: INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BRDT-BD1 and BRDT-BD2 with IC50 values of 44 nM, 5 nM, 9 nM, 1 nM, 28 nM, 3 nM, 119 nM and 63 nM respectively.
Molecular Weight: 348, 36