Product Overview
Indibulin | T15576 | TargetMol Chemicals
CAS: 204205-90-3
Smiles: Clc1ccc(Cn2cc(C(=O)C(=O)Nc3ccncc3)c3ccccc23)cc1
Formula: C22H16ClN3O2
Pathway: Apoptosis|||Cytoskeletal Signaling
Target: Apoptosis|||Microtubule Associated
Receptor: N/A
Bioactivity: Indibulin is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis.
Molecular Weight: 389, 84
