Indirubin-3'-monoxime | T5200

Indirubin-3'-monoxime | T5200 | TargetMol Chemicals

CAS: 160807-49-8

Smiles: O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccccc12

Formula: C16H11N3O2

Pathway: Cell Cycle/Checkpoint|||Metabolism|||PI3K/Akt/mTOR signaling|||Stem Cells

Target: GSK-3|||Lipoxygenase|||CDK

Receptor: N/A

Bioactivity: Indirubin-3'-oxime is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E).

Molecular Weight: 277, 283